Acetaminophen hepatotoxicity is the leading cause of drug-induced liver failure. Despite
substantial efforts in the past, the mechanisms of acetaminophen-induced liver cell injury are …

Acetaminophen (APAP) hepatotoxicity is currently the single most important cause of acute
liver failure in the US, and is associated with a significant number of deaths. The toxic …

Neutrophils are recruited into the liver after acetaminophen (AAP) overdose but the
pathophysiological relevance of this acute inflammatory response remains unclear. To …

This investigation elucidates the role of free radicals in acetaminophen (AA)-induced toxicity
and the possible protection by resveratrol (RVT). BALB-c mice were injected with a single …

Administration of high doses of the histamine antagonist methapyrilene to rats causes
periportal liver necrosis. The mechanism of toxicity is ill-defined and here we have utilized …

The mode of cell death after acetaminophen (AAP) overdose is controversially discussed. A
recent study reported a protective effect of the pancaspase inhibitor Z-VAD-fmk against AAP …

Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. In
addition to inducing direct cellular damage, oxidants can activate transcription factors …

The protective effect of β-glucan against oxidative injury caused by acetaminophen was
studied in mice liver. BALB-c mice (25–30 g) were pre-treated with β-d-glucan (50 mg/kg …

The objective of this study was to determine whether Toll-like receptor 4 (TLR4) has a role in
alcohol-mediated acetaminophen (APAP) hepatotoxicity. TLR4 is involved in the …

Acetaminophen overdose is a leading cause of drug-related acute liver failure in the United
States. Glutathione, a tripeptide antioxidant protects cells against oxidative damage from …