Huntington's disease (HD) is a hereditary and fatal disorder caused by an expanded CAG
triplet repeat in the HD gene, resulting in a mutant form of the protein huntingtin. Wild‐type …

Huntington's disease (HD) is a progressive neurodegenerative disorder that generally
begins in middle age with abnormalities of movement, cognition, personality, and mood …

Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase
cleavage fragments represents an early pathological change in brains of Huntington's …

Post-translational modification by the lipid palmitate is crucial for the correct targeting and
function of many proteins. Here we show that huntingtin (htt) is normally palmitoylated at …

Thirteen years ago, the culmination of genetic rather than biochemical strategies resulted in
the identification of the root cause of Huntington's disease: an expanded CAG trinucleotide …

Transcriptional dysregulation caused by expanded polyglutamines (polyGlns) in huntingtin
(htt) may be central to cell-autonomous mechanisms for neuronal cell death in Huntington's …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, which is
caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat …

Insoluble aggregated proteins in Alzheimer disease and Huntington disease might not be
pathogenic. Human studies have poor correlations between aggregates and clinical disease …

Huntingtin's critical cleavage | Nature Neuroscience Skip to main content Thank you for visiting
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Huntington's disease (HD) is one of at least nine inherited neurodegenerative disorders
caused by polyglutamine (polyQ) repeat expansion in the associated disease proteins. In …