It is well recognized that high-density lipoprotein (HDL)-cholesterol is antiatherogenic and
serves a role in mediating cholesterol efflux from cells. However, HDL has multiple …

Thrombosis occurs in a dynamic rheological field that constantly changes as the thrombus
grows to occlusive dimensions. In the initiation of thrombosis, flow conditions near the vessel …

Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation
cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading …

Apoptosis and vascular cell activation are main contributors to the release of procoagulant
microparticles (MPs), deleterious partners in atherothrombosis. Elevated levels of circulating …

Although the presence of subcellular procoagulant particles in highly centrifuged plasma
has been known for many years, it was not until 1967 that shed membrane procoagulant …

Tissue factor (TF) is an essential cofactor for the activation of blood coagulation in vivo. We
now report that quiescent human platelets express TF pre-mRNA and, in response to …

Cell membrane microparticles (MPs) circulate in the blood of healthy donors, and their
elevated counts have been documented in various pathologies. Microparticles are …

Tissue factor (TF) exhibits a distinct nonuniform tissue distribution. Thus, high levels are
found in highly vascularized organs such as the lung, brain, and placenta; intermediate …

The role of the collagen receptor glycoprotein VI (GPVI) in arteriolar thrombus formation was
studied in FcRγ-null mice (FcRγ–/–) lacking platelet surface GPVI. Thrombi were induced …

Individuals with chronically elevated glucose and/or insulin levels, ie, most patients with type
2 diabetes, have accelerated atherosclerosis and are prone to acute vascular events. We …