Cerebral amyloid angiopathy of the β‐amyloid type (Aβ‐CAA) is a risk factor for hemorrhagic
stroke and independently is believed to contribute to dementia. Naturally occurring animal …

Objective: To provide an updated overview of the methods used in genetic, transcriptomic,
and proteomic studies in Alzheimer's disease and to demonstrate the importance of those …

Mutations in human presenilin (PS) genes cause aggressive forms of familial Alzheimer's
disease. Presenilins are polytopic proteins that harbour the catalytic site of the γ‐secretase …

The varied ways in which mutations in presenilins (PSEN1 and PSEN2) affect amyloid b
precursor protein (APP) processing in causing early‐onset familial Alzheimer disease (FAD) …

Aβ40 and Aβ42 are the major forms of amyloid β peptides (Aβ) in the brain. Although Aβ42
differs from Aβ40 by only two residues, Aβ42 is much more prone to aggregation and more …

Since the first report showing that Alzheimer disease (AD) might be caused by mutations in
the amyloid precursor protein gene (APP), 20 different missense mutations have been …

Alzheimer's disease (AD) is a genetically complex and heterogenous disorder. In a small
proportion of cases, mutations in three determinative (causal) genes are responsible for …

Transgenic mouse models of Alzheimer's disease (AD) expressing high levels of amyloid
precursor protein (APP) with familial AD (FAD) mutations have proven to be extremely useful …

Abstract Beta-site APP Cleaving Enzyme 1 (BACE1) is a key enzyme in the generation of P-
amyloid, the major component of senile plaques in the brains of Alzheimer's Disease …

Page 1 ACTA BIOMEDICA LOVANIENSIA Jos TOURNOY PHYSIOLOGICAL STUDY OF
PRESENILINS AND BACES, TWO PROTEASES INVOLVED IN THE PATHOGENESIS OF …