Beyond the dogma: novel β2-adrenoceptor signalling in the airways

MA Giembycz, R Newton - European Respiratory Journal, 2006 - Eur Respiratory Soc
β2-Adrenoceptor agonists evoke rapid bronchodilatation and are the mainstay of the
treatment of asthma symptoms worldwide. The mechanism of action of this class of …

New therapies for asthma

PJ Barnes - Trends in molecular medicine, 2006 - cell.com
Asthma is an increasing global health problem, and many patients continue to suffer from
chronic symptoms. However, current therapy with inhaled corticosteroids and a long-acting …

The effective treatment of COPD: anticholinergics and what else?

M Cazzola, MG Matera - Drug Discovery Today: Therapeutic Strategies, 2006 - Elsevier
Long-acting bronchodilator therapy should be considered when a COPD patient is
symptomatic. For patients whose conditions are not sufficiently controlled by monotherapy …

Emerging drugs for the treatment of chronic obstructive pulmonary disease

S Malhotra, SFP Man, DD Sin - Expert Opinion on Emerging Drugs, 2006 - Taylor & Francis
By 2020 chronic obstructive pulmonary disease (COPD) will be the third leading cause of
mortality and fifth leading cause of morbidity. Research over the past two decades has shed …

Biological targets for therapeutic interventions in COPD: clinical potential

G Pelaia, A Vatrella, L Gallelli, T Renda… - … Journal of Chronic …, 2006 - Taylor & Francis
COPD is a widespread inflammatory respiratory disorder characterized by a progressive,
poorly reversible airflow limitation. Currently available therapies are mostly based on those …

Progress in the development of Inhaled, long-acting β2-adrenoceptor agonists

PA Glossop, DA Price - Annual Reports in Medicinal Chemistry, 2006 - Elsevier
Publisher Summary Long acting β 2-adrenoceptor agonists are a highly precedented drug
class used for the treatment of asthma and chronic obstructive pulmonary disease (COPD) …

Are there any realistic chances to develop new drugs for asthma?

A Amon, A Pahl, I Szelenyi - Drug News & Perspectives, 2006 - europepmc.org
Asthma bronchiale, an inflammatory airway disease, imposes a significant health care
problem worldwide. It is characterized by three critical phenotypic traits: intermittent and …

Glycopyrrolate combinations for the treatment of respiratory diseases: Sofotec GmbH & Co. KG: US20050175548, US20050175549 & US20050175547

A Guerra, NE Campillo, JA Páez - Expert Opinion on Therapeutic …, 2006 - Taylor & Francis
This paper analyses three patents, published in 2005 by Sofotec GmbH & Co. KG, for the
treatment of respiratory diseases that include asthma and chronic obstructive pulmonary …

Effects of asthma treatment: the present and future

GP Currie - Expert Review of Clinical Immunology, 2006 - Taylor & Francis
The increasing burden of asthma in both primary and secondary care has led to extensive
research into its genetics, pathophysiology and treatment over the past few decades …

Long-acting β2 agonists: Pfizer: US20050171147 & US20050182091

P Norman - Expert Opinion on Therapeutic Patents, 2006 - Taylor & Francis
Two applications claim very closely related arylsulfonamide β2-agonists. The basic generic
claim is the same in both cases with subsidiary claims covering different permutations of the …