Current insights into the regulation of programmed cell death by NF-κB
J Dutta, Y Fan, N Gupta, G Fan, C Gelinas - Oncogene, 2006 - nature.com
The nuclear factor-kappaB (NF-κB) transcription factors have emerged as major regulators
of programmed cell death (PCD) whether via apoptosis or necrosis. In this context, NF-κB's …
of programmed cell death (PCD) whether via apoptosis or necrosis. In this context, NF-κB's …
Cellular and molecular mechanisms of liver tolerance
The liver exhibits a distinctive form of immune privilege, termed liver tolerance, in which
orthotopic liver transplantation results in systemic donor‐specific T‐cell tolerance, while …
orthotopic liver transplantation results in systemic donor‐specific T‐cell tolerance, while …
Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor–related apoptosis-inducing ligand …
S Radaeva, R Sun, B Jaruga, VT Nguyen, Z Tian… - Gastroenterology, 2006 - Elsevier
Background & Aims: Viral hepatitis infection, which is a major cause of liver fibrosis, is
associated with activation of innate immunity. However, the role of innate immunity in liver …
associated with activation of innate immunity. However, the role of innate immunity in liver …
PD-L1 is induced in hepatocytes by viral infection and by interferon-α and-γ and mediates T cell apoptosis
M Mühlbauer, M Fleck, C Schütz, T Weiss, M Froh… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: B7-H1 (PD-L1) is a B7-family member that binds to programmed
death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in …
death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in …
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC
A Melhem, N Muhanna, A Bishara, CE Alvarez… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: We have investigated the role of natural killer (NK) cells in hepatic
fibrogenesis. Mouse NK cells express both inhibitory/activating-killing-immunoglobulin …
fibrogenesis. Mouse NK cells express both inhibitory/activating-killing-immunoglobulin …
B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts
J Hori, M Wang, M Miyashita, K Tanemoto… - The Journal of …, 2006 - journals.aai.org
Abstract The programmed death-1 (PD-1) costimulatory pathway has been demonstrated to
play a role in the regulation of immune responses and peripheral tolerance. We investigated …
play a role in the regulation of immune responses and peripheral tolerance. We investigated …
[PDF][PDF] In vivo immune modulatory activity of hepatic stellate cells in mice
CH Chen, LM Kuo, Y Chang, W Wu, C Goldbach… - …, 2006 - Wiley Online Library
Accumulating data suggest that hepatic tolerance, initially demonstrated by spontaneous
acceptance of liver allografts in many species, results from an immune regulatory activity …
acceptance of liver allografts in many species, results from an immune regulatory activity …
[HTML][HTML] Immunoregulatory role of B7-H1 in chronicity of inflammatory responses
Pathogenesis of most chronic human diseases, including chronic infections, autoimmune
diseases and cancers, often involves a persistent, unresolved inflammatory response. The …
diseases and cancers, often involves a persistent, unresolved inflammatory response. The …
Allergic hepatitis induced by drugs
JV Castell, M Castell - Current opinion in allergy and clinical …, 2006 - journals.lww.com
Drug-induced liver injury is of concern due to its unpredictable nature and serious clinical
implications. Clinically, both hepatocellular injury and cholestasis can occur and most …
implications. Clinically, both hepatocellular injury and cholestasis can occur and most …
Activation-induced cell death of hepatic stellate cells by the innate immune system
WZ Mehal - Gastroenterology, 2006 - gastrojournal.org
Hepatic stellate cells (HSC) are key mediators of the changes that transform a healthy liver
into a cirrhotic liver. They are multifunctional, laying down collagen, remodeling matrix …
into a cirrhotic liver. They are multifunctional, laying down collagen, remodeling matrix …