The nuclear factor-kappaB (NF-κB) transcription factors have emerged as major regulators
of programmed cell death (PCD) whether via apoptosis or necrosis. In this context, NF-κB's …

The liver exhibits a distinctive form of immune privilege, termed liver tolerance, in which
orthotopic liver transplantation results in systemic donor‐specific T‐cell tolerance, while …

Background & Aims: Viral hepatitis infection, which is a major cause of liver fibrosis, is
associated with activation of innate immunity. However, the role of innate immunity in liver …

BACKGROUND/AIMS: B7-H1 (PD-L1) is a B7-family member that binds to programmed
death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated to result in …

BACKGROUND/AIMS: We have investigated the role of natural killer (NK) cells in hepatic
fibrogenesis. Mouse NK cells express both inhibitory/activating-killing-immunoglobulin …

Abstract The programmed death-1 (PD-1) costimulatory pathway has been demonstrated to
play a role in the regulation of immune responses and peripheral tolerance. We investigated …

Accumulating data suggest that hepatic tolerance, initially demonstrated by spontaneous
acceptance of liver allografts in many species, results from an immune regulatory activity …

Pathogenesis of most chronic human diseases, including chronic infections, autoimmune
diseases and cancers, often involves a persistent, unresolved inflammatory response. The …

Drug-induced liver injury is of concern due to its unpredictable nature and serious clinical
implications. Clinically, both hepatocellular injury and cholestasis can occur and most …

Hepatic stellate cells (HSC) are key mediators of the changes that transform a healthy liver
into a cirrhotic liver. They are multifunctional, laying down collagen, remodeling matrix …