Guanidinium cations are a prominent recognition motif for oxoanion binding both in Nature
and in abiotic systems. However, simple ion pairing based on alkyl guanidinium cations is …

β-Sheets and α-helices are the two principal secondary structures in proteins. However, our
understanding of β-sheet structure lags behind that of α-helices, largely because, until …

This article describes the selective recognition and noncovalent dimerization of N-terminal
aromatic peptides in aqueous solution by the synthetic host compound, cucurbit [8] uril (Q8) …

Peptide dendrimers built by iteration of the diamino acid dendron Dap-His-Ser (His=
histidine, Ser= Serine, Dap= diamino propionic acid) display a strong positive dendritic effect …

An artificial dipeptide receptor (1) was designed and observed to bind the deprotonated
dipeptide Ac‐d‐Ala‐d‐Ala‐OH in buffered water with K= 33 100 m− 1, whereas other …

Whereas in the classical combinatorial approach mainly large but completely random
libraries are used, nowadays also the use of small but designed libraries is coming into …

This report covers some highlights in chemical genetics published during 2005. It is
interesting to note that, in addition to the increasingly creative approaches being developed …

The binding of small oligopeptides by artificial receptors under physiological conditions (in
water) still remains a challenging task. Although early work in this area was limited to …