In the decade since the discovery that mouse B cells respond to certain unmethylated CpG
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …

The article identifies the commonality in chronic inflammatory diseases like periodontitis,
diabetes, and coronary artery disease. These kinds of diseases are observed in a significant …

Toll-like receptors (TLRs) were evolved to detect invading pathogens and to induce innate
immune responses in order to mount host defense mechanisms. It becomes apparent that …

Nuclear factor κB (NF-κB) activation by NF-κB-inducing kinase (NIK)–IκBα kinase (IKK)
pathway and mitogen-activated protein kinases (MAPKs) pathway are important in …

Abstract CC chemokine ligand 1 (CCL1; I-309) is a CC chemokine that interacts with CC
chemokine receptor 8, which is preferentially expressed in polarized T helper cell type 2 and …

TLRs play a crucial role in early host defense against invading pathogens. In the
seminiferous epithelium, Sertoli cells are the somatic nurse cells that mechanically …

A novel member of the IκB family, human IκB-ζ, was identified by a differential screening
approach of apoptosis-sensitive and-resistant tumor cells. The protein consists of 6 ankyrin …

The low-grade, chronic, systemic inflammatory state that characterizes the aging process
(inflammaging) results from late evolutive-based expression of the innate immune system …

The objective of this study was to evaluate the negative regulatory role of heat shock protein
70 (HSP70) on endotoxin-induced activation of inflammatory cytokine signaling pathways in …

Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids.
TLR9 is expressed in intracellular compartments where it responds specifically to pathogen …