Lead discovery is currently a key bottleneck in the pipeline for much-needed novel drugs for
tropical diseases such as malaria, tuberculosis, African sleeping sickness, leishmaniasis …

Some development stages of the trypanosomatid protozoan parasites are well adapted to in
vitro culture. They can be maintained in rich medium containing large excess of glucose and …

Even before the publication of Darwin's Origin of Species, the perception of evolutionary
change has been a tree-like pattern of diversification-with divergent branches spreading …

Five years ago, little was known about kinetoplastid evolution. Recent improvements in the
taxon sampling for nuclear rRNA genes and several protein markers have transformed this …

CD8+ T cells are crucial for control of a number of medically important protozoan parasites,
including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the …

Three common systemic human fungal pathogens—Cryptococcus neoformans, Candida
albicans and Aspergillus fumigatus—have retained all the machinery to engage in sexual …

The neglected tropical diseases represent a group of parasitic and bacterial diseases,
occurring primarily in rural areas or impoverished urban areas of developing countries …

Trypanosoma brucei and the other members of the trypanosomatid family of parasitic
protozoa, contain an unusual RNA polymerase II enzyme, uncoordinated mRNA 5 …

This review represents the first attempt to define the origins of the major P450-containing
pathways in plants. Comparative genomics with five complete P450 gene sets from …

Human infection by the vector‐borne protozoan Leishmania is responsible for substantial
worldwide morbidity and mortality. The surface‐metalloprotease (leishmanolysin) of …