Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

The study of chemical exchange processes is one of the oldest and still most vigorously
investigated topics in NMR spectroscopy. The effects of chemical exchange on the NMR …

Previous studies using MR spectroscopy have shown that the extracellular pH (pHe) of
tumors is acidic compared to normal tissues. This has a number of important sequelae that …

While simultaneous breakthroughs occurring in molecular biology and nanoscience/
technology will ultimately revolutionize all of medicine, it is with our efforts to prevent …

Magnetic resonance imaging (MRI) provides exquisite anatomic detail of various organs and
is capable of providing additional functional information. This combination allows for …

Since nanotechnology is considered a key for the 21st century, its promises have been
assessed by various scientific communities. By meeting at the nanoscale, various …

New improved pH-sensitive nitroxides were applied for in vivo studies. An increased stability
of the probes towards reduction was achieved by the introduction of the bulky ethyl groups in …

Here we describe the combined use of acid-labile microgel approach and RAFT-mediated
seeded dispersion polymerization technique to prepare an acid-cleavable core–shell like …

Abstracts Noninvasive techniques for measurement of tissue pH can be invaluable in
assessing disease extent and response to therapy in a variety of pathological conditions …

Amphiphilic block copolymers often form core-shell type micelles by self-organization of the
blocks in an aqueous medium or under specific experimental conditions. Polymeric micelles …