The use of biomarkers is of ever-increasing importance in clinical diagnosis of disease. In
practice, a cutpoint is required for dichotomizing naturally continuous biomarker levels to …

In order to compare the discriminatory effectiveness of two diagnostic markers the equality of
the areas under the respective Receiver Operating Characteristic Curves is commonly …

Paratuberculosis (Johne's disease) is a significant animal health problem. Evaluation of
diagnostic tests for Johne's disease has been difficult due to lack of a gold standard test. In …

I read with1 interest the excellent and timely article by Reis Miranda and colleagues (1).
Nevertheless, I am concerned that the authors and the editors permitted the use of the term …

Recent scientific and technological innovations have produced an abundance of potential
markers which are being investigated for their use in disease screen-ing and diagnosis. In …