Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α is a member of a family of
transcription coactivators that plays a central role in the regulation of cellular energy …

Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as
inducible coregulators of nuclear receptors in the control of cellular energy metabolic …

Many biological programs are regulated at the transcriptional level. This is generally
achieved by the concerted actions of several transcription factors. Recent findings have …

AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake …

Recent studies using magnetic resonance spectroscopy have shown that decreased insulin-
stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport …

Type 2 diabetes mellitus is a major cause of morbidity and mortality worldwide, and the
prevalence is set to increase dramatically over the coming decades. Understanding the …

Skeletal muscle constitutes the largest insulin‐sensitive tissue in the body and is the primary
site for insulin‐stimulated glucose utilization. Skeletal muscle resistance to insulin is …

While it has been known for more than 75 years that physical activity is associated with
increased mitochondrial content in muscle, the molecular mechanism for this adaptive …

Type 2 Diabetes results from a complex physiologic process that includes the pancreatic
beta cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and …

Interleukin (IL)-6 is a pleiotropic hormone that has both proinflammatory and anti-
inflammatory actions. AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that …