Cell‐penetrating peptides (CPPs) are capable of introducing a wide range of cargoes into
living cells. Descriptions of the internalization process vary from energy‐independent cell …

Replication of nuclear DNA in eukaryotes presents a tremendous challenge, not only due to
the size and complexity of the genome, but also because of the time constraint imposed by a …

Lipid phosphates are potent mediators of cell signaling and control processes including
development, cell migration and division, blood vessel formation, wound repair, and tumor …

Since the 1950's, herpes simplex viruses (HSV) have played prominent roles in the
development of antivirals. The first efficacious antivirals, as well as the first safe for systemic …

The proliferating cell nuclear antigen (PCNA) is a homotrimeric ring‐shaped protein that, by
encircling DNA, may function as a sliding platform for proteins participating in various DNA …

Most DNA synthesis in HeLa cell nucleus is concentrated in discrete foci. These synthetic
sites can be identified by electron microscopy after allowing permeabilized cells to elongate …

Deregulated cell growth and inhibition of apoptosis are hallmarks of cancer. All-trans retinoic
acid induces clinical remission in patients with acute promyelocytic leukemia by inhibiting …

Replication of the entire genome during S-phase is one of the most important cell cycle
events and requires the coordinated activity of a multitude of different enzymes. Proliferating …

Many phospholipids are signaling molecules that regulate cell proliferation, survival,
apoptosis, adhesion, and migration. Bioactive lipid phosphate signaling is instrumental in …

The cell cycle is driven by the oscillating activity of a class of protein called cyclin-dependent
kinases (CDKs). By definition, CDKs are activated by binding to cyclins. The oscillating …