The hippocampus is one of several limbic brain structures implicated in the pathophysiology
and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and …

Accumulating evidence implicates hippocampal neurogenesis in the pathophysiology of
depression. Psychosocial stress reduces neurogenesis in rodents, whereas chronic …

Disability in life functioning is an important and poorly understood consequence of major
depressive disorder (MDD). Mood symptoms do not account for the magnitude of disability …

In this review of the last 5 years' developments in research into depression we focus on
recent advances and current controversies. We cover epidemiology and basic science as …

Objective: Studies of subjects with dementia of the Alzheimer type have reported
correlations between increases in activity of the hypothalamic-pituitary-adrenal (HPA) axis …

It has been hypothesized that a decrease in the synthesis of new neurons in the adult
hippocampus might be linked to major depressive disorder (MDD). This hypothesis arose …

Stem cells generate neurons in discrete regions in the postnatal mammalian brain.
However, the extent of neurogenesis in the adult human brain has been difficult to establish …

BACKGROUND: A frequent polymorphism of the brain-derived neurotrophic factor (BDNF)
gene (val66met) has been suggested to modulate hippocampal neuronal plasticity and has …

Depression is a devastating illness with a lifetime prevalence of up to 20%. The
neurotransmitter serotonin or 5-hydroxytryptamine (5-HT) is involved in the pathophysiology …

Clinical and pathological data from the Rush Memory and Aging Project were used to test
the hypothesis that distress proneness is associated with increased risk of Alzheimer's …