ERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad
range of cellular activities and physiological processes. ERK1/2 can be activated transiently …

Initially described as a satiety factor with neuroendocrine properties, leptin has been shown
to regulate immune and inflammatory processes. Mainly produced by white adipose tissue …

Abstract Lyng, FM, Maguire, P., McClean, B., Seymour, C. and Mothersill, C. The
Involvement of Calcium and MAP Kinase Signaling Pathways in the Production of Radiation …

VEGF receptor-2 plays a critical role in endothelial cell proliferation during angiogenesis.
However, regulation of receptor activity remains incompletely explained. Here, we …

Selective cell death of dopaminergic neurons in the substantia nigra is the major cause of
Parkinson disease. Current evidence suggests that this cell death could be mediated by …

Several human diseases have been associated with the overproduction of reactive oxygen
species (ROS) and subsequently various antioxidants emerged as potential therapeutic …

Rat primary chondrocytes express the sphingosine-1-phosphate (S1P) receptor, S1P2,
S1P3, S1P4, but not S1P1. When chondrocytes were stimulated with S1P or …

Aralia cordata were determined by measuring (1) GAG and collagen expression,(2) GAG
and collagen degrada-tion,(3) TIMP and MMPs expression, and (4) TIMP and MMPs activity …

The reason that the anterior cruciate ligament (ACL) has a very poor healing potential after
injury is not well understood. In this study, we investigated the role of nitric oxide (NO) in the …

Nitric oxide (NO), a highly reactive gaseous molecule, has been previously reported to
induce apoptosis-like cell death even at a low concentration in PC12 cells. In this study, we …