AMP-activated protein kinase signaling in metabolic regulation
YC Long, JR Zierath - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake …
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake …
LKB1-dependent signaling pathways
This review focuses on remarkable recent findings concerning the mechanism by which the
LKB1 protein kinase that is mutated in Peutz-Jeghers cancer syndrome operates as a tumor …
LKB1 protein kinase that is mutated in Peutz-Jeghers cancer syndrome operates as a tumor …
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
Mutation in the TSC2 tumor suppressor causes tuberous sclerosis complex, a disease
characterized by hamartoma formation in multiple tissues. TSC2 inhibits cell growth by …
characterized by hamartoma formation in multiple tissues. TSC2 inhibits cell growth by …
AMP‐activated protein kinase–development of the energy sensor concept
The LKB1→ AMPK cascade is switched on by metabolic stresses that either inhibit ATP
production (eg hypoxia, hypoglycaemia) or that accelerate ATP consumption (eg muscle …
production (eg hypoxia, hypoglycaemia) or that accelerate ATP consumption (eg muscle …
Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
It is now becoming evident that the liver has an important role in the control of whole body
metabolism of energy nutrients. In this review, we focus on recent findings showing that AMP …
metabolism of energy nutrients. In this review, we focus on recent findings showing that AMP …
Metformin inhibits cytokine-induced nuclear factor κB activation via AMP-activated protein kinase activation in vascular endothelial cells
Y Hattori, K Suzuki, S Hattori, K Kasai - Hypertension, 2006 - Am Heart Assoc
AMP-activated protein kinase (AMPK) is tightly regulated by the cellular AMP: ATP ratio and
plays a central role in regulation of energy homeostasis and metabolic stress. Metformin has …
plays a central role in regulation of energy homeostasis and metabolic stress. Metformin has …
AMPK: a key sensor of fuel and energy status in skeletal muscle
DG Hardie, K Sakamoto - Physiology, 2006 - journals.physiology.org
Contraction induces marked metabolic changes in muscle, and the AMP-activated protein
kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle …
kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle …
AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1
WJ Lee, M Kim, HS Park, HS Kim, MJ Jeon… - Biochemical and …, 2006 - Elsevier
AMP-activated protein kinase (AMPK) activation increases fatty acid oxidation in skeletal
muscle by decreasing malonyl CoA concentrations. However, this may not explain the long …
muscle by decreasing malonyl CoA concentrations. However, this may not explain the long …
Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
M Suter, U Riek, R Tuerk, U Schlattner… - Journal of Biological …, 2006 - ASBMB
AMP-activated protein kinase (AMPK) is a heterotrimeric protein kinase that is crucial for
cellular energy homeostasis of eukaryotic cells and organisms. Here we report on the …
cellular energy homeostasis of eukaryotic cells and organisms. Here we report on the …
Skeletal muscle lipid metabolism in exercise and insulin resistance
B Kiens - Physiological reviews, 2006 - journals.physiology.org
Lipids as fuel for energy provision originate from different sources: albumin-bound long-
chain fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins …
chain fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins …