Immune and inflammatory mechanisms in neuropathic pain

G Moalem, DJ Tracey - Brain research reviews, 2006 - Elsevier
Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders

JW Phillis, LA Horrocks, AA Farooqui - Brain research reviews, 2006 - Elsevier
Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

Activated microglia contribute to the maintenance of chronic pain after spinal cord injury

BC Hains, SG Waxman - Journal of Neuroscience, 2006 - Soc Neuroscience
Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons …

ZY Zhuang, YR Wen, DR Zhang, T Borsello… - Journal of …, 2006 - Soc Neuroscience
Optimal management of neuropathic pain is a major clinical challenge. We investigated the
involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve …

Endogenous opiates and behavior: 2005

RJ Bodnar, GE Klein - Peptides, 2006 - Elsevier
This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Spatial and temporal relationship between monocyte chemoattractant protein‐1 expression and spinal glial activation following peripheral nerve injury

J Zhang, Y De Koninck - Journal of neurochemistry, 2006 - Wiley Online Library
Peripheral nerve injury can induce spinal microglial/astrocyte activation. Substances
released by activated glial cells excite spinal nociceptive neurons. Pharmacological …

The function of microglia through purinergic receptors: neuropathic pain and cytokine release

K Inoue - Pharmacology & therapeutics, 2006 - Elsevier
Microglia play an important role as immune cells in the central nervous system (CNS).
Microglia are activated in threatened physiological homeostasis, including CNS trauma …

The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets

RR Myers, WM Campana, VI Shubayev - Drug discovery today, 2006 - Elsevier
Neuroinflammation is a proinflammatory cytokine-mediated process that can be provoked by
systemic tissue injury but it is most often associated with direct injury to the nervous system …

Mechanisms of disease: pain in fibromyalgia syndrome

R Staud, ME Rodriguez - Nature clinical practice Rheumatology, 2006 - nature.com
Despite extensive research, the pathogenesis of pain in fibromyalgia syndrome is
incompletely understood. Fibromyalgia pain is consistently felt in deep tissues including …

Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury

ZG Piao, IH Cho, CK Park, JP Hong, SY Choi, SJ Lee… - Pain, 2006 - journals.lww.com
Glial activation is known to contribute to pain hypersensitivity following spinal sensory nerve
injury. In this study, we investigated mechanisms by which glial cell activation in medullary …