Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …

Optimal management of neuropathic pain is a major clinical challenge. We investigated the
involvement of c-Jun N-terminal kinase (JNK) in neuropathic pain produced by spinal nerve …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Peripheral nerve injury can induce spinal microglial/astrocyte activation. Substances
released by activated glial cells excite spinal nociceptive neurons. Pharmacological …

Microglia play an important role as immune cells in the central nervous system (CNS).
Microglia are activated in threatened physiological homeostasis, including CNS trauma …

Neuroinflammation is a proinflammatory cytokine-mediated process that can be provoked by
systemic tissue injury but it is most often associated with direct injury to the nervous system …

Despite extensive research, the pathogenesis of pain in fibromyalgia syndrome is
incompletely understood. Fibromyalgia pain is consistently felt in deep tissues including …

Glial activation is known to contribute to pain hypersensitivity following spinal sensory nerve
injury. In this study, we investigated mechanisms by which glial cell activation in medullary …