The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …

We have previously shown that activation of the acid sphingomyelinase (ASM), the release
of ceramide and the formation of ceramide-enriched membrane domains are central for the …

Central elements in the infection of mammalian cells with viral, bacterial and parasitic
pathogens include the adhesion of the pathogen to surface receptors of the cell, recruitment …

Death of cancer cells influences tumor development and progression, as well as the
response to anticancer therapies. This can occur through different cell death programmes …

Bacterial peritonitis remains a serious complication of peritoneal dialysis. Although
Staphylococcus epidermidis is the most common pathogen involved, infections with …

Apoptosis, or programmed cell death (PCD), is an important physiological mechanism,
through which the human immune system regulates homeostasis and responds to diverse …

The era of sphingolipid-based therapeutics is upon us. A large body of work has been
accumulating that demonstrates the distinct biological roles of sphingolipids in maintaining a …

The pathogen Staphylococcus aureus causes a diversity of diseases that range from minor
skin and soft tissue infections to life‐threatening systemic infections. S. aureus‐endothelial …

Recent studies indicate that the reorganization of receptor molecules in distinct domains of
the cell membrane constitutes an important and general mechanism that is required for the …