Biomarkers of cardiovascular disease: molecular basis and practical considerations

RS Vasan - Circulation, 2006 - Am Heart Assoc
echocardiogram) may be expected to facilitate the identification of patients with chest pain of
an ischemic etiology (angina). In a patient presenting to the emergency department with …

Positive natural selection in the human lineage

PC Sabeti, SF Schaffner, B Fry, J Lohmueller, P Varilly… - science, 2006 - science.org
Positive natural selection is the force that drives the increase in prevalence of advantageous
traits, and it has played a central role in our development as a species. Until recently, the …

[图书][B] Radiobiology for the Radiologist

EJ Hall, AJ Giaccia - 2006 - redjournal.org
Many refer to the textbook Radiobiology for the Radiologist as the “bible” of radiation biology
for educating residents, researchers, and clinicians. Dr. Eric Hall has compiled, written, and …

[HTML][HTML] A bivalent chromatin structure marks key developmental genes in embryonic stem cells

BE Bernstein, TS Mikkelsen, X Xie, M Kamal… - Cell, 2006 - cell.com
The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster
within regions enriched for genes encoding developmentally important transcription factors …

A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters

S Saxonov, P Berg, DL Brutlag - Proceedings of the …, 2006 - National Acad Sciences
A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs)
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …

Counting the zinc-proteins encoded in the human genome

C Andreini, L Banci, I Bertini… - Journal of proteome …, 2006 - ACS Publications
Metalloproteins are proteins capable of binding one or more metal ions, which may be
required for their biological function, or for regulation of their activities or for structural …

DNA methylation profiling of human chromosomes 6, 20 and 22

F Eckhardt, J Lewin, R Cortese, VK Rakyan, J Attwood… - Nature …, 2006 - nature.com
DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

[HTML][HTML] Alternative splicing: new insights from global analyses

BJ Blencowe - Cell, 2006 - cell.com
Recent analyses of sequence and microarray data have suggested that alternative splicing
plays a major role in the generation of proteomic and functional diversity in metazoan …

Genetics and genomics of core short tandem repeat loci used in human identity testing

JM Butler - Journal of forensic sciences, 2006 - Wiley Online Library
Over the past decade, the human identity testing community has settled on a set of core
short tandem repeat (STR) loci that are widely used for DNA typing applications. A variety of …

ERK1/2 MAP kinases in cell survival and apoptosis

Z Lu, S Xu - IUBMB life, 2006 - Wiley Online Library
ERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad
range of cellular activities and physiological processes. ERK1/2 can be activated transiently …