Heterozygous familial hypercholesterolemia: an underrecognized cause of early cardiovascular disease

G Yuan, J Wang, RA Hegele - Cmaj, 2006 - Can Med Assoc
Heterozygous familial hypercholesterolemia (HeFH) is a monogenic disorder that affects
about 1 in 500 people, with a higher prevalence in certain subpopulations such as people of …

Diagnosis and screening for familial hypercholesterolaemia: finding the patients, finding the genes

D Bhatnagar - Annals of clinical biochemistry, 2006 - journals.sagepub.com
Familial hypercholesterolaemia (FH) is a genetic disorder in which the concentration of
serum cholesterol is elevated from birth and leads to premature coronary heart disease. FH …

Influence of HDL cholesterol on preclinical carotid atherosclerosis in familial hypercholesterolemia

M Junyent, M Cofán, I Núnez, R Gilabert… - … , and vascular biology, 2006 - Am Heart Assoc
Objective—The effect of risk factors on carotid atherosclerosis in heterozygous familial
hypercholesterolemia (FH) is unclear. We evaluated carotid intima-media thickness (IMT) by …

Genetics of apolipoprotein B and apolipoprotein AI and premature coronary artery disease

A Zambon, BG Brown, SS Deeb… - Journal of internal …, 2006 - Wiley Online Library
Increased low‐density lipoprotein (LDL) and decreased high‐density lipoprotein cholesterol
(HDL‐C) predict premature coronary artery disease, as do elevated levels of apolipoprotein …

Recent developments in the treatment of atherosclerosis

PS Brahmkshatriya, MH Jani… - Journal of Enzyme …, 2006 - Taylor & Francis
Atherosclerosis is one of the most frequent causes of cardiac arrest. The major cause of this
disease is high concentrations of lipid in the blood. Medicinal agents so far have been quite …

ORIGINAL ARTICLE Monogenic hypercholesterolaemias–an evaluation of apolipoprotein B100 and LDL receptor gene polymorphisms

R Plewa, M Łuczak, P Burchardt… - Polish Heart …, 2006 - journals.viamedica.pl
Introduction: Normally the N-terminal domain of the LDL receptor (LDLR) binds to low-
density lipoprotein through apolipoprotein B100. Mutations within the LDL receptor and/or …

Risk assessment and the impact of ecogenetics

EM Faustman, G Omenn - Gene-environment Interactions …, 2006 - Wiley Online Library
How does the current risk assessment process, designed to predict human risk, address the
inherent variability within the human population? How will the growing discipline of …

[图书][B] Utilidad de la ecografía de alta resolución en la valoración de la aterosclerosis preclínica, riesgo cardiovascular y diagnóstico de la hipercolesterolemia familiar

M Junyent Priu - 2006 - diposit.ub.edu
[spa] La presente tesis valora la utilidad de la ecografía carotídea de alta resolución, como
técnica diagnóstica incruenta, útil, validada, reproducible y de bajo coste que nos permite …

[PDF][PDF] PORODIČNA ISTORIJA BOLESTI KAO FAKTOR RIZIKA ZA NASTANAK AKUTNOG INFARKTA MIOKARDA

Z Deljanin, N Rančić, B Tiodorović, B Petrović, M Ilić - publisher.medfak.ni.ac.rs
Infarkt miokarda (IM) je kompleksna bolest koja nastaje doživotnom interakcijom genetskih i
faktora iz okruženja. Cilj ove studije bio je da se dokaže porodična istorija bolesti kao faktor …

[HTML][HTML] Pharmacokinetics, efficacy, and safety of pravastatin in children: Studies in children with heterozygous familial hypercholesterolemia and in pediatric cardiac …

M Koskinen - 2006 - helda.helsinki.fi
Background. Hyperlipidemia is a common concern in patients with heterozygous familial
hypercholesterolemia (HeFH) and in cardiac transplant recipients. In both groups, an …