Most infectious agents enter the body at mucosal surfaces and therefore mucosal immune
responses function as a first line of defence. Protective mucosal immune responses are most …

Adult pulmonary Langerhans' cell histiocytosis is a rare disorder of unknown aetiology that
occurs predominantly in young smokers, with an incidence peak at 20–40 yrs of age. In …

Langerhans cells (LCs) are the only dendritic cells of the epidermis and constitute the first
immunological barrier against pathogens and environmental insults. The factors regulating …

The nature of dendritic cell (s)(DC [s]) that conditions efficient in vivo priming of CD8+ CTL
after immunization via epithelial tissues remains largely unknown. Here, we show that …

Chronic obstructive pulmonary disease (COPD) is mainly caused by cigarette smoking, and
is characterized by an increase in inflammatory cells in the airways and pulmonary tissue …

To help understand the role of chemokines in NK cell trafficking, we determined the
chemokine receptor profiles of three different human NK cell lines and freshly isolated …

T cell activation by dendritic cells (DCs) is critical to the initiation of adaptive immune
responses and protection against pathogens. Here, we demonstrate that a specialized DC …

The CCR6 chemokine receptor is expressed by most B cells and subsets of T cells and
dendritic cells (DCs) found in the gut mucosal immune system. CCL20, the single …

Initiation of adaptive mucosal immunity occurs in organized mucosal lymphoid tissues such
as Peyer's patches of the small intestine. Mucosal lymphoid follicles are covered by a …

In this study, we explored dermal dendritic cell (DC) homeostasis in mice and humans both
in the steady state and after hematopoietic cell transplantation. We discovered that dermal …