Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …

An individual's ability to move reflects the contractile response of skeletal muscle after action
potentials from innervating motor neurons trigger the release of the neurotransmitter …

Amyotrophic lateral sclerosis (ALS) is a rare disease involving selective and progressive
degeneration and disappearance of motor neurons. Oxidative stress is believed to …

Background & Aims: Brain-derived neurotrophic factor (BDNF) acts rapidly to modulate
synaptic neurotransmission in the brain. Although present in neurons, glial cells, and …

Neurotrophic factors (NTFs) have the unique potential to support neuronal survival and to
augment neuronal function in the injured and diseased nervous system. Numerous studies …

The aim of this study was to determine the predictors of disease progression in a group of
832 patients with the diagnosis of definite or probable amyotrophic lateral sclerosis (ALS) …

Brain‐derived neurotrophic factor (BDNF) is a protein that promotes the survival of neurons.
It is widely thought to possess clinical potential for the treatment of neurodegenerative …

The angiogenic activity of vascular endothelial growth factor (VEGF) is well known. Recently,
it has become evident that VEGF is involved in central nervous system physiology and may …

AIT-082 is a purine derivative with neuroprotective and neurotrophic activity that is desirable
in a candidate therapy for Amyotrophic Lateral Sclerosis. Consequently, we investigated the …

In vitro and in vivo studies conducted over the last 20 years have shown that neurotrophic
factors can prevent neuronal cell death and augment neuronal function in rodent and …