Gender and sex hormones influence the response to trauma and sepsis: potential therapeutic approaches
MK Angele, MC Frantz, IH Chaudry - Clinics, 2006 - SciELO Brasil
Several clinical and experimental studies have demonstrated gender dimorphism in immune
and organ responsiveness and in the susceptibility to and morbidity from shock, trauma, and …
and organ responsiveness and in the susceptibility to and morbidity from shock, trauma, and …
Jak/STAT/SOCS signaling circuits and associated cytokine-mediated inflammation and hypertrophy in the heart
AM Terrell, PR Crisostomo, GM Wairiuko, M Wang… - Shock, 2006 - journals.lww.com
Cytokines are important mediators of cardiac disease. Accumulating evidence indicates that
members of the interleukin-6 family of cytokines promote cardiac hypertrophy through the …
members of the interleukin-6 family of cytokines promote cardiac hypertrophy through the …
Estrogen receptor-α mediates acute myocardial protection in females
M Wang, P Crisostomo, GM Wairiuko… - American Journal of …, 2006 - journals.physiology.org
Sex differences in myocardial recovery have been reported after acute ischemia and
reperfusion injury. Estrogen and the estrogen receptor are critical determinants of …
reperfusion injury. Estrogen and the estrogen receptor are critical determinants of …
High passage number of stem cells adversely affects stem cell activation and myocardial protection
PR Crisostomo, M Wang, GM Wairiuko, ED Morrell… - Shock, 2006 - journals.lww.com
Progenitor cell plasticity enhances positive remodeling of damaged tissue. We and others
have previously shown that progenitor cells may limit apoptosis and modulate inflammation …
have previously shown that progenitor cells may limit apoptosis and modulate inflammation …
Upregulation of mitochondrial respiratory complex IV by estrogen receptor-β is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions …
YC Hsieh, HP Yu, T Suzuki, MA Choudhry… - Journal of molecular and …, 2006 - Elsevier
Our recent study showed that estrogen receptor (ER) β plays a major role in mediating the
salutary effects of 17β-estradiol (E2) on cardiac function following trauma–hemorrhage (T …
salutary effects of 17β-estradiol (E2) on cardiac function following trauma–hemorrhage (T …
Sex differences in coxsackievirus B3-induced myocarditis: IL-12Rβ1 signaling and IFN-γ increase inflammation in males independent from STAT4
S Frisancho-Kiss, JF Nyland, SE Davis, JA Frisancho… - Brain research, 2006 - Elsevier
Cardiovascular disease is the number one killer of men and women in North America. Male
BALB/c mice infected with coxsackievirus B3 (CVB3) develop more severe inflammatory …
BALB/c mice infected with coxsackievirus B3 (CVB3) develop more severe inflammatory …
Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-β agonist: up-regulation of cardiac heat shock factor-1 and heat …
HP Yu, T Shimizu, MA Choudhry, YC Hsieh… - Journal of molecular and …, 2006 - Elsevier
Although 17β-estradiol (E2) administration following trauma-hemorrhage (TH) improves
cardiac function in male rodents, it is not known whether the salutary effects of E2 are …
cardiac function in male rodents, it is not known whether the salutary effects of E2 are …
Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage
HP Yu, T Shimizu, YC Hsieh, T Suzuki… - Journal of leukocyte …, 2006 - academic.oup.com
Abstract Although 17β-estradiol (E2) administration after trauma-hemorrhage (TH) reduces
tissue neutrophil sequestration in male rodents, it remains unknown which of the estrogen …
tissue neutrophil sequestration in male rodents, it remains unknown which of the estrogen …
Inhibition of cardiac PGC‐1α expression abolishes ERβ agonist‐mediated cardioprotection following trauma‐hemorrhage
YC Hsieh, MA Choudhry, Y Huang-Ping… - The FASEB …, 2006 - Wiley Online Library
ABSTRACT PGC‐1α (peroxisome proliferator‐acti‐vated receptor [PPARγ] coactivator‐1α)
activates PPARα and mitochondrial transcription factor A (Tfam), which regulate proteins …
activates PPARα and mitochondrial transcription factor A (Tfam), which regulate proteins …
Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia
M Wang, BM Tsai, PR Crisostomo, DR Meldrum - Shock, 2006 - journals.lww.com
Cardiogenic shock from myocardial ischemia is the leading cause of death of both men and
women. Although adult progenitor cells have emerged as a potential therapy for heart …
women. Although adult progenitor cells have emerged as a potential therapy for heart …