Abstract Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates
vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular …

Biomarkers provide a powerful and dynamic approach to understanding the spectrum of
malignancies with applications in observational and analytic epidemiology, randomized …

Chromosome rearrangement, a hallmark of cancer, has profound effects on carcinogenesis
and tumor phenotype. We used a panel of 60 human cancer cell lines (the NCI-60) as a …

Telomerase reactivation is a hallmark of human carcinogenesis. Increased telomerase
activity may result from gene amplification and/or overexpression. This study evaluates the …

Mutations in the PIK3CA gene have recently been reported in different human neoplasms,
including breast cancer. This paper reports the results of a systematic analysis of PIK3CA …

Chromosomal regions harboring tumor suppressors and oncogenes are often deleted or
amplified. Array comparative genomic hybridization detects segmental DNA copy number …

Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-β (TGF-
β); however, the mechanism of this resistance remains unclear. We used oligonucleotide …

Lung cancer is one of the most common cancers worldwide and its pathogenesis is closely
associated with tobacco smoking. Continuous exposure of smoking carcinogens results in …

The transactivation of nuclear receptors is regulated by both ligand binding and
phosphorylation. We previously showed that RARα (retinoic acid receptor α) …

Background Formalin-fixed paraffin-embedded (FFPE) tissues represent the largest source
of archival biological material available for genomic studies of human cancer. Therefore, it is …