Type I inteferon gene induction by the interferon regulatory factor family of transcription factors
K Honda, A Takaoka, T Taniguchi - Immunity, 2006 - cell.com
Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate
immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll …
immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll …
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
K Honda, T Taniguchi - Nature Reviews Immunology, 2006 - nature.com
The interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown …
involved in the induction of genes that encode type I interferons. IRFs have now been shown …
5'-Triphosphate RNA is the ligand for RIG-I
The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm
of virally infected cells is largely unknown. We demonstrated that the 5′-triphosphate end of …
of virally infected cells is largely unknown. We demonstrated that the 5′-triphosphate end of …
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates
A Pichlmair, O Schulz, CP Tan, TI Näslund… - Science, 2006 - science.org
Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical
trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic …
trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic …
NF-κB and the immune response
One of the primary physiological roles of nuclear factor-kappa B (NF-κB) is in the immune
system. In particular, NF-κB family members control the transcription of cytokines and …
system. In particular, NF-κB family members control the transcription of cytokines and …
[HTML][HTML] Type I interferons in host defense
DB Stetson, R Medzhitov - Immunity, 2006 - cell.com
Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to
viruses and other intracellular infections. In the past several years, many of the receptors …
viruses and other intracellular infections. In the past several years, many of the receptors …
Regulation and function of IKK and IKK-related kinases
H Hacker, M Karin - Science's STKE, 2006 - science.org
Members of the nuclear factor kappa B (NF-κB) family of dimeric transcription factors (TFs)
regulate expression of a large number of genes involved in immune responses …
regulate expression of a large number of genes involved in immune responses …
Intracellular pattern recognition receptors in the host response
The innate immune system relies on its capacity to rapidly detect invading pathogenic
microbes as foreign and eliminate them. Indeed, Toll-like receptors are a class of membrane …
microbes as foreign and eliminate them. Indeed, Toll-like receptors are a class of membrane …
Recognition and signaling by toll-like receptors
Toll-like receptors (TLRs) are transmembrane proteins that detect invading pathogens by
binding conserved, microbially derived molecules and that induce signaling cascades for …
binding conserved, microbially derived molecules and that induce signaling cascades for …
TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity
EM Creagh, LAJ O'Neill - Trends in immunology, 2006 - cell.com
Significant advances in our understanding of innate immunity have been made following the
identification of three families of pathogen sensors: Toll-like receptors (TLRs), NOD-like …
identification of three families of pathogen sensors: Toll-like receptors (TLRs), NOD-like …