Epidermal growth factor receptor (EGFR) is overexpressed in several epithelial
malignancies, including head and neck squamous cell carcinoma (HNSCC), which exhibits …

The LH surge causes major remodeling of the ovarian follicle in preparation for the ovulatory
process. These changes include reprogramming of granulosa cells to differentiate into luteal …

The greatest risk factor for developing carcinoma of the prostate is advanced age. Potential
molecular and physiologic contributors to the frequency of cancer occurrence in older …

A disintegrin and metalloprotease (ADAM) is a membrane-anchored metalloprotease
implicated in the ectodomain shedding of cell surface proteins, including the ligands for …

The epidermal growth factor receptor is a member of type-I growth factor receptor family with
tyrosine kinase activity that is activated following the binding of multiple cognate ligands …

Patients with primary brain tumors have bleak prognoses and there is an urgent desire to
identify new markers for sensitive diagnosis and new therapeutic targets for effective …

The exact role of ad isintegrin and metalloproteinase with thrombospondin motifs-1
(ADAMTS-1) and the underlying mechanism of its involvement in tumor metastasis have not …

Hepatocellular carcinoma is a major cause of cancer-related deaths. Current treatments are
not effective, and the identification of relevant pathways and novel therapeutic targets are …

Amphiregulin (AR) autocrine loops have been associated with several types of cancer. We
demonstrate that SUM149 breast cancer cells have a self-sustaining AR autocrine loop …

Epidermal growth factor (EGF)-like proteins comprise a group of structurally similar growth
factors, which contain a conserved six-cysteine residue motif called the EGF-domain. EGF …