Background and Purpose—This guideline provides an overview of the evidence on various
established and potential stroke risk factors and provides recommendations for the reduction …

Aspirin resistance is the inability of aspirin to reduce platelet production of thromboxane A 2
and thereby platelet activation and aggregation. Increasing degrees of aspirin resistance …

Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) show indisputable
promise as chemopreventive agents. Possible targets include cancers of the colon, stomach …

Reports of the predictive value of minor elevation of serum C-reactive protein (CRP) levels
(between 3 and 10 mg/L) for atherosclerotic events have generated considerable interest, as …

Objectives: Although the concept of aspirin resistance is extensively reported in medical
literature, its precise mechanisms and clinical outcomes are largely unknown. In this study …

Inflammation is now considered critical in the pathogenesis of myocardial infarction. One of
the mechanisms regulating the inflammatory process is the ubiquitin-proteasome system …

COX-2-dependent prostaglandin (PG) E 2 synthesis regulates macrophage MMP
expression, which is thought to destabilize atherosclerotic plaques. However, the …

Inflammation plays a central role in the development of atherosclerotic disease, from the
early phases of lesion formation to plaque disruption, the main underlying cause of acute …

Membrane lipids supply the substrate for the synthesis of eicosanoids and platelet-activating
factor. Eicosanoids—arachidonate metabolites, including prostaglandins, prostacyclin …

Rationale: The majority of patients with sarcoidosis resolve their condition; however 5–10%
of patients with sarcoidosis develop pulmonary fibrosis with poor prognosis. Prostaglandin …