During the past 5 years, gene expression studies in cell culture, animal models and in the
brains of patients have shown that the perturbation of transcription frequently results in …

Many human inherited neurodegenerative disorders are characterized by loss of balance
due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations …

Background Previous studies have demonstrated reexpression of cell-cycle markers within
postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD) …

In the Drosophila eye, proteins with an expanded polyglutamine (polyQ) tract form nuclear
and cytoplasmic inclusions and produce cytotoxicity, demonstrated as loss of eye …

A large yeast two-hybrid study investigating whether the proteins mutated in different forms
of spinocerebellar ataxia have interacting protein partners in common suggests that some …

Spinocerebellar ataxia type 1 (SCA1) is an incurable neurodegenerative disease resulting
from loss of Purkinje neurones within the cerebellum. The ubiquitin proteasome pathway …

Background. Previous studies have demonstrated re-expression of cell-cycle markers within
postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD) …