The abilities to sense environmental and internal temperatures are required for survival,
both for maintenance of homeostasis and for avoidance of tissue-damaging noxious …

Severe chronic pain afflicts a large number of people worldwide but satisfactory relief from
such pain is difficult to achieve with drugs that are currently available, and so there is a great …

Background and aims: Neutrophins are involved in somatic and visceral hypersensitivity.
The action of nerve growth factor (NGF) on sensory neurones contributes to the …

The extracellular signal-regulated kinase (Erk) cascades are suggested to contribute to
excitatory synaptic plasticity in the CNS, including the spinal cord dorsal horn. However …

This study attempted to accelerate the peripheral nerve regeneration, using the high outflow
rate of asymmetric poly (dl-lactic acid-co-glycolic acid)(PLGA) nerve conduits. Asymmetric …

The rostral ventromedial medulla (RVM) has recently received considerable attention in
efforts to understand mechanisms of hyperalgesia and persistent pain states. Three classes …

It is well established that the voltage-gated calcium (Ca2+) channels can modulate neuronal
activity in the peripheral and central nervous system causing a variety of behavioral and …

Some of the earliest detailed descriptions of biophysical properties of low voltage-activated
(LVA) or transient (T) type Ca2+ channels were done using in vitro preparation of primary …

Neuropeptide Y has been implicated in pain modulation and is substantially up-regulated in
dorsal root ganglia after peripheral nerve injury. To identify the role of neuropeptide Y after …

Pain is defined by the International Association for the Study of Pain (IASP) as an
unpleasant sensory and emotional experience associated with actual or potential tissue …