Trp ion channels and temperature sensation

A Dhaka, V Viswanath, A Patapoutian - Annu. Rev. Neurosci., 2006 - annualreviews.org
The abilities to sense environmental and internal temperatures are required for survival,
both for maintenance of homeostasis and for avoidance of tissue-damaging noxious …

Targeting N-type and T-type calcium channels for the treatment of pain

JG McGivern - Drug discovery today, 2006 - Elsevier
Severe chronic pain afflicts a large number of people worldwide but satisfactory relief from
such pain is difficult to achieve with drugs that are currently available, and so there is a great …

Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat

L Delafoy, A Gelot, D Ardid, A Eschalier, C Bertrand… - Gut, 2006 - gut.bmj.com
Background and aims: Neutrophins are involved in somatic and visceral hypersensitivity.
The action of nerve growth factor (NGF) on sensory neurones contributes to the …

Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice

F Wei, KI Vadakkan, H Toyoda, LJ Wu… - Journal of …, 2006 - Soc Neuroscience
The extracellular signal-regulated kinase (Erk) cascades are suggested to contribute to
excitatory synaptic plasticity in the CNS, including the spinal cord dorsal horn. However …

The effect of high outflow permeability in asymmetric poly (dl-lactic acid-co-glycolic acid) conduits for peripheral nerve regeneration

CJ Chang, S Hsu - Biomaterials, 2006 - Elsevier
This study attempted to accelerate the peripheral nerve regeneration, using the high outflow
rate of asymmetric poly (dl-lactic acid-co-glycolic acid)(PLGA) nerve conduits. Asymmetric …

Role for medullary pain facilitating neurons in secondary thermal hyperalgesia

W Kincaid, MJ Neubert, M Xu, CJ Kim… - Journal of …, 2006 - journals.physiology.org
The rostral ventromedial medulla (RVM) has recently received considerable attention in
efforts to understand mechanisms of hyperalgesia and persistent pain states. Three classes …

The role of T-type calcium channels in peripheral and central pain processing

SM Todorovic… - CNS & Neurological …, 2006 - ingentaconnect.com
It is well established that the voltage-gated calcium (Ca2+) channels can modulate neuronal
activity in the peripheral and central nervous system causing a variety of behavioral and …

The role of peripheral T-type calcium channels in pain transmission

V Jevtovic-Todorovic, SM Todorovic - Cell calcium, 2006 - Elsevier
Some of the earliest detailed descriptions of biophysical properties of low voltage-activated
(LVA) or transient (T) type Ca2+ channels were done using in vitro preparation of primary …

Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers

TJS Shi, J Li, A Dahlström, E Theodorsson, S Ceccatelli… - Neuroscience, 2006 - Elsevier
Neuropeptide Y has been implicated in pain modulation and is substantially up-regulated in
dorsal root ganglia after peripheral nerve injury. To identify the role of neuropeptide Y after …

[图书][B] Functional neuroanatomy of the pain system

KG Usunoff, A Popratiloff, O Schmitt, A Wree - 2006 - Springer
Pain is defined by the International Association for the Study of Pain (IASP) as an
unpleasant sensory and emotional experience associated with actual or potential tissue …