NF-κ B activity is elevated in a high proportion of cancers, particularly advanced cancers that
have been treated previously. Cytotoxic treatment selects for such up-regulation inasmuch …

Insulin-like growth factor-I (IGF-I) has gained broad recognition as an important survival
factor for epithelial cells in numerous tissues. The IGF-I receptor signaling pathway is …

The microtubule-targeting compound paclitaxel is often used in the treatment of endocrine-
resistant or metastatic breast cancer. We have previously shown that apoptosis of breast …

Bim, the Bcl-2 interacting mediator of cell death, is a member of the BH3-only family of pro-
apoptotic proteins. Recent studies have demonstrated that the apoptotic activity of Bim can …

FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of
FOXO proteins relies on their ability to control diverse and at times, opposing cellular …

Mutations in gld-1 cause lethal germline tumors in the nematode Caenorhabditis elegans.
We find that a wide variety of mutations that extend C. elegans' life span confer resistance to …

Diabetic nephropathy (DN) is characterized by mesangial cell (MC) expansion and
accumulation of extracellular matrix proteins. TGF-β is increased in MC under diabetic …

In this study, we have identified the Forkhead transcription factor FoxM1 as a physiological
regulator of estrogen receptor α (ERα) expression in breast carcinoma cells. Our survey of a …

The integrity of the feto-maternal interface is critical for survival of the conceptus. This
interface, consisting of the maternal decidua and the invading placental trophoblast, is …

Menstruation, or cyclic shedding of nonpregnant endometrial tissue with associated
bleeding, occurs only in humans and a few other species. This breakdown of the …