After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …

▪ Abstract CB1 and CB2 cannabinoid receptors are the primary targets of endogenous
cannabinoids (endocannabinoids). These G protein–coupled receptors play an important …

The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical
allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat …

Long-term cannabinoid administration produces region-dependent CB1 receptor
desensitization and down-regulation. This study examined the time course for normalization …

Cannabinoids act on various regions in the nervous system to modulate neuronal activity
including nociception. Here, we investigated CB1 receptor expression in primary afferent …

Lipids are essential components of plasma-and organelle-membranes, not only providing a
frame for embedded proteins (eg, receptors and ion channels) but also functioning as …

Abstract N-arachidonoylethanolamide (anandamide [AEA]) is the main endocannabinoid
described to date in the testis. It exerts its effects through the activation of G-protein coupled …

The phytocannabinoid cannabidiol (CBD) is at the forefront of therapeutic cannabinoid
research due to its non-psychotropic properties. Research supports its use in a variety of …

METHODS Reverse transcriptase polymerase chain reaction: All procedures were
performed in accordance with the ARVO Statement for the Use of Animals in Ophthalmic and …

Cannabinoids, acting through the CB1 cannabinoid receptor (CB1R), protect the brain
against ischemia and related forms of injury. This may involve inhibiting the neurotoxicity of …