It has long been established that type 1 diabetes (T1D) is a T cell-mediated autoimmune
disease, with CD4+ and CD8+ T cells being largely responsible for the destruction of β cells …

Abstract Wild-type (WT) NOD. H-2h4 mice develop spontaneous autoimmune thyroiditis
(SAT) when given 0.05% NaI in their drinking water, whereas B cell–deficient NOD. H-2h4 …

The determinant spreading of T cell autoimmunity plays an important role in the
pathogenesis of type 1 diabetes and in the protective mechanism of Ag-based …

Developing B cells undergo selection at multiple checkpoints to eliminate autoreactive
clones. We analyzed B cell kinetics in the NOD mouse to establish whether these …

Autoreactive T cells clearly mediate the pancreatic β cell destruction causing type 1 diabetes
(T1D). However, studies in NOD mice indicate that B cells also contribute to pathogenesis …

B Zellen sind die zellulären Träger einer gegen Infektionserreger gerichteten, humoralen
und protektiven Immunität. In der Entstehung von Autoimmunerkrankungen und in der …

Tolerance to self in the B cell repertoire is governed by the nature of the autoantigen and by
the stage in B lymphocyte development at which antigen encounter occurs. Many self …

Self-reactive B lymphocytes are frequently produced as a consequence of B cell antigen
receptor rearrangement. Autoreactive B cells that are not eliminated or inactivated by …