Cancer stem cells are cancer cells that originate from the transformation of normal stem
cells. The most important property of any stem cell is the ability to self-renew. Through this …

Kallmann syndrome (KS) is a disorder characterized by hypogonadotropic hypogonadism
and anosmia. Although KS is genetically heterogeneous, only two causal genes have been …

Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-
hindbrain region during development. Although the only difference between these isoforms …

Abstract The Saethre–Chotzen syndrome (SCS) is an autosomal dominant craniosynostosis
syndrome with uni-or bilateral coronal synostosis and mild limb deformities. It is caused by …

BACKGROUND/PURPOSE: Despite the similar clinical phenotype of the Saethre-Chotzen
and Muenke craniosynostoses, the 2 syndromes are now genotypically distinct. Patients with …

The epidermal growth factor receptor (EGFR) variant Xmrk of the Mexican fish Xiphophorus
is one of the first oncogenes described. Its overexpression in pigment cells of the skin occurs …

Using a genetic approach, an increasing number of genes has been shown to be important
for proper skull vault development. In this review, we discuss the genes involved in disorders …

Les causes et les mécanismes à l'origine de la fusion prématurée des sutures crâniennes
sont encore incomplètement connus. Il s' agit presque toujours d'un événement anténatal …

The human head represents an astonishing evolutionary achievement. It houses the brain
and the special sense organs of vision, hearing, balance, taste and olfaction; it provides the …

The activating mutation FGFR3-R248C in the D2–D3 linker region of fibroblast growth factor
receptor 3 leads as germline mutation to the neonatal lethal syndrome thanatophoric …