The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his
article “IL-6: A Cytokine for Gerontologists,” indicated IL-6 as one of the main signaling …

Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria
and New Perspectives from Syste Page 1 Current Pharmaceutical Design, 2006, 12, 3161-3171 …

Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a
strong genetic component appears to have an impact on survival to extreme ages. In order …

The plasma levels of dehydroepiandrosterone (DHEA) and its sulfated form (DHEAS)
decline∼ 80% between the ages of 25 and 75 yr. Muscle mass and strength also decrease …

Old-age survival has improved substantially since 1950 in developed countries. As a result
the number of octogenarians has increased four-fold, the number of nonagenarians eight …

Undernutrition profoundly affects immune responses, particularly at the extremities of life: in
infants and in the elderly. The present review focuses on this interrelationship in the elderly …

With ageing the immune system is deregulated and this leads to the development of
immunosenescence mainly affecting the adaptive immune response. There is much …

This review focuses on possible causes and the impact of different immune states in
schizophrenia and major depression. It discusses the fact that, in schizophrenia, an over …

Background: Inflammation is known to affect sulfur amino acid metabolism. Aging is
associated with an increased prevalence of inflammatory conditions, but the metabolism of …

There is considerable controversy about the molecular mechanisms responsible for the
variations in innate immunity associated with age. While in vivo, aged animals and humans …