Asthma genetics 2006: the long and winding road to gene discovery
C Ober, S Hoffjan - Genes & Immunity, 2006 - nature.com
Asthma and atopy are complex phenotypes that are influenced by both genetic and
environmental factors. A review of nearly 500 papers on disease association studies …
environmental factors. A review of nearly 500 papers on disease association studies …
Update on glucocorticoid action and resistance
Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …
molecules that have been optimized to target activity to the lung and minimize systemic …
Asthma in hispanics
GM Hunninghake, ST Weiss… - American Journal of …, 2006 - atsjournals.org
Hispanic individuals trace their ancestry to countries that were previously under Spanish
rule, including Mexico, large parts of Central and South America, and some Caribbean …
rule, including Mexico, large parts of Central and South America, and some Caribbean …
Airway remodeling and airway smooth muscle in asthma
M Munakata - Allergology International, 2006 - jstage.jst.go.jp
Airway remodeling in asthma has been recognized as structural changes of airways such as
smooth muscle hypertrophy (an increase in size of airway smooth muscle cells) and …
smooth muscle hypertrophy (an increase in size of airway smooth muscle cells) and …
The genetic basis of ankylosing spondylitis
JD Reveille - Current opinion in rheumatology, 2006 - journals.lww.com
Nearly half of the susceptibility to ankylosing spondylitis is provided by major
histocompatibility complex genes. Non-major histocompatibility complex genes, most …
histocompatibility complex genes. Non-major histocompatibility complex genes, most …
Genetic polymorphisms in arginase I and II and childhood asthma and atopy
H Li, I Romieu, JJ Sienra-Monge… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: A recent microarray study implicated arginase I (ARG1) and arginase II
(ARG2) in mouse allergic asthma models and human asthma. OBJECTIVES: To examine …
(ARG2) in mouse allergic asthma models and human asthma. OBJECTIVES: To examine …
The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
M Schedel, M Depner, C Schoen, SK Weiland… - Respiratory …, 2006 - Springer
Background ADAM33, the first asthma candidate gene identified by positional cloning, may
be associated with childhood asthma, lung function decline and bronchial …
be associated with childhood asthma, lung function decline and bronchial …
Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I
V Bernier, R Stocco, MJ Bogusky, JG Joyce… - Journal of Biological …, 2006 - ASBMB
Neuropeptide S (NPS) and its receptor (NPSR) are thought to have a role in asthma
pathogenesis; a number of single nucleotide polymorphisms within NPSR have been shown …
pathogenesis; a number of single nucleotide polymorphisms within NPSR have been shown …
Gene–Environment Interaction in Asthma
GH Koppelman, DS Postma - Genetics of Asthma and Chronic …, 2006 - api.taylorfrancis.com
Asthma is a genetically complex disease, caused by multiple genes and mul-tiple
environmental factors that may interact. Epidemiological studies haveprovided suggestive …
environmental factors that may interact. Epidemiological studies haveprovided suggestive …
Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci
T Kurz, S Hoffjan, MG Hayes, D Schneider… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Genome-wide linkage scans to identify asthma susceptibility loci have
revealed many linked regions, including a broad region on chromosome 5p. OBJECTIVE: To …
revealed many linked regions, including a broad region on chromosome 5p. OBJECTIVE: To …