The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells
DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
DS Shames, L Girard, B Gao, M Sato, CM Lewis… - PLoS …, 2006 - journals.plos.org
Background Promoter hypermethylation coupled with loss of heterozygosity at the same
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …
The RASSF1A tumor suppressor activates Bax via MOAP-1
MD Vos, A Dallol, K Eckfeld, NPC Allen… - Journal of Biological …, 2006 - ASBMB
The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis
by promoter methylation. RASSF1A may serve as a node in the integration of signaling …
by promoter methylation. RASSF1A may serve as a node in the integration of signaling …
Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis
P Minoo, K Baker, R Goswami, G Chong, WD Foulkes… - Gut, 2006 - gut.bmj.com
Background: Hyperplastic polyposis of the colorectum is a precancerous condition that has
been linked with DNA methylation. The polyps in this condition have been distinguished …
been linked with DNA methylation. The polyps in this condition have been distinguished …
DNA methylation profiles of female steroid hormone-driven human malignancies
M Campan, DJ Weisenberger, PW Laird - DNA Methylation: Development …, 2006 - Springer
Tumor DNA contains valuable clues about the origin and pathogenesis of human cancers.
Alterations in DNA methylation can lead to silencing of genes associated with distinct …
Alterations in DNA methylation can lead to silencing of genes associated with distinct …
Detection of RASSF1A and RAR? Hypermethylation in Serum DNA from Breast Cancer Patients
Breast cancer is fast emerging as the leading cancer amongst females, especially in young
females in metropolitan cities in India. The epigenetic alterations involved in the onset and …
females in metropolitan cities in India. The epigenetic alterations involved in the onset and …
Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma
P Lázcoz, J Muñoz, M Nistal, Á Pestaña, I Encío… - BMC cancer, 2006 - Springer
Background Epigenetic alterations and loss of heterozygosity are mechanisms of tumor
suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has …
suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has …
Aberrant hypermethylation of RASSF1A promoter in ovarian borderline tumors and carcinomas
Abstract The newly identified 3p21. 3 tumor suppressor gene RASSF1A is inactivated by
hypermethylation in variable solid tumors, including those of the lung, breast, prostate …
hypermethylation in variable solid tumors, including those of the lung, breast, prostate …
DNA methylation-dependent epigenetic regulation of gene expression in MCF-7 breast cancer cells
AG Rivenbark, WD Jones, JD Risher, WB Coleman - Epigenetics, 2006 - Taylor & Francis
To identify epigenetically-regulated genes in breast cancer, MCF-7 cells were exposed to
250nM 5-aza or 5-aza+ 50nM TSA for 3 weeks followed by a 5 week recovery period after …
250nM 5-aza or 5-aza+ 50nM TSA for 3 weeks followed by a 5 week recovery period after …
Ras association domain family 1C protein stimulates human lung cancer cell proliferation
YG Amaar, MG Minera, LK Hatran… - … of Physiology-Lung …, 2006 - journals.physiology.org
Recently, the Ras association domain family 1 gene (RASSF1) has been identified as a Ras
effector encoding two major mRNA forms, RASSF1A and RASSF1C, derived by alternative …
effector encoding two major mRNA forms, RASSF1A and RASSF1C, derived by alternative …