DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …

Background Promoter hypermethylation coupled with loss of heterozygosity at the same
locus results in loss of gene function in many tumor cells. The “rules” governing which genes …

The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis
by promoter methylation. RASSF1A may serve as a node in the integration of signaling …

Background: Hyperplastic polyposis of the colorectum is a precancerous condition that has
been linked with DNA methylation. The polyps in this condition have been distinguished …

Tumor DNA contains valuable clues about the origin and pathogenesis of human cancers.
Alterations in DNA methylation can lead to silencing of genes associated with distinct …

Breast cancer is fast emerging as the leading cancer amongst females, especially in young
females in metropolitan cities in India. The epigenetic alterations involved in the onset and …

Background Epigenetic alterations and loss of heterozygosity are mechanisms of tumor
suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has …

Abstract The newly identified 3p21. 3 tumor suppressor gene RASSF1A is inactivated by
hypermethylation in variable solid tumors, including those of the lung, breast, prostate …

To identify epigenetically-regulated genes in breast cancer, MCF-7 cells were exposed to
250nM 5-aza or 5-aza+ 50nM TSA for 3 weeks followed by a 5 week recovery period after …

Recently, the Ras association domain family 1 gene (RASSF1) has been identified as a Ras
effector encoding two major mRNA forms, RASSF1A and RASSF1C, derived by alternative …