Self-tolerance of natural killer cells
Natural killer (NK) cells, similar to other lymphocytes, acquire tolerance to self. This means
that NK cells have the potential to attack normal self cells but that there are mechanisms to …
that NK cells have the potential to attack normal self cells but that there are mechanisms to …
Licensing of natural killer cells by self‐major histocompatibility complex class I
WM Yokoyama, S Kim - Immunological reviews, 2006 - Wiley Online Library
Natural killer (NK) cells have potent capacities to immediately kill cellular targets and
produce cytokines that may potentially damage normal self‐tissues unless they are kept in …
produce cytokines that may potentially damage normal self‐tissues unless they are kept in …
T cell–and B cell–independent adaptive immunity mediated by natural killer cells
JG O'Leary, M Goodarzi, DL Drayton… - Nature …, 2006 - nature.com
It is commonly believed that only T lymphocytes and B lymphocytes expressing
recombination-dependent antigen-specific receptors mediate contact hypersensitivity …
recombination-dependent antigen-specific receptors mediate contact hypersensitivity …
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC
A Melhem, N Muhanna, A Bishara, CE Alvarez… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: We have investigated the role of natural killer (NK) cells in hepatic
fibrogenesis. Mouse NK cells express both inhibitory/activating-killing-immunoglobulin …
fibrogenesis. Mouse NK cells express both inhibitory/activating-killing-immunoglobulin …
Activation and self‐tolerance of natural killer cells
Natural killer (NK) cells are regulated by numerous stimulatory and inhibitory receptors that
recognize various classes of cell surface ligands, some of which are expressed by normal …
recognize various classes of cell surface ligands, some of which are expressed by normal …
Missing self recognition and self tolerance of natural killer (NK) cells
DH Raulet - Seminars in immunology, 2006 - Elsevier
Natural killer cells express inhibitory receptors specific for polymorphic MHC molecules,
which enables them to mediate “missing self recognition”, the capacity to attack self cells that …
which enables them to mediate “missing self recognition”, the capacity to attack self cells that …
NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors
Z Fan, P Yu, Y Wang, Y Wang, ML Fu, W Liu, Y Sun… - Blood, 2006 - ashpublications.org
Natural killer (NK) cells are generally reported as innate effector cells for killing virally
infected and transformed cells. It is unclear how NK cells evoke adaptive immunity to …
infected and transformed cells. It is unclear how NK cells evoke adaptive immunity to …
Strategies of natural killer cell recognition and signaling
The participation of natural killer (NK) cells in multiple aspects of innate and adaptive
immune responses is supported by the wide array of stimulatory and inhibitory receptors …
immune responses is supported by the wide array of stimulatory and inhibitory receptors …
Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors
L Deng, RA Mariuzza - Seminars in immunology, 2006 - Elsevier
Natural killer (NK) cell function is regulated by NK cell receptors that bind classical MHC
class I molecules or their structural relatives. The latter group includes self-ligands (MICA …
class I molecules or their structural relatives. The latter group includes self-ligands (MICA …
The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions
S Malarkannan - Seminars in immunology, 2006 - Elsevier
NK cells use NKG2D receptor to recognize 'induced-self'. In apparent violation of the
'missing-self'hypothesis, NK cells stimulated through NKG2D can lyse target cells despite …
'missing-self'hypothesis, NK cells stimulated through NKG2D can lyse target cells despite …