Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression

DS Basseres, AS Baldwin - Oncogene, 2006 - nature.com
Abundant data support a key role for the transcription factor nuclear factor-κB (NF-κB)
signaling pathway in controlling the initiation and progression of human cancer. NF-κB and …

Multiple endocrine neoplasia type 1

F Marini, A Falchetti, FD Monte, SC Sala… - Orphanet journal of rare …, 2006 - Springer
Abstract Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant
hereditary cancer syndrome presented mostly by tumours of the parathyroids, endocrine …

Menin links estrogen receptor activation to histone H3K4 trimethylation

KMA Dreijerink, KW Mulder, GS Winkler… - Cancer research, 2006 - AACR
The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene,
menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes …

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression

YX Chen, J Yan, K Keeshan… - Proceedings of the …, 2006 - National Acad Sciences
Menin is the product of the tumor suppressor gene Men1 that is mutated in the inherited
tumor syndrome multiple endocrine neoplasia type 1 (MEN1). Menin has been shown to …

Multiple endocrine neoplasia type 1

RV Thakker - Principles of Molecular Medicine, 2006 - Springer
Multiple endocrine neoplasia type 1 (MEN1) is characterized by the combined occurrence of
tumors of the parathyroids, pancreatic islets, and anterior pituitary. In addition, some patients …

Menin and its interacting proteins: elucidation of menin function

K Balogh, K Rácz, A Patócs, L Hunyady - Trends in Endocrinology & …, 2006 - cell.com
The multiple endocrine neoplasia type 1 (MEN1) gene is a tumor suppressor gene encoding
a 610 amino acid nuclear protein, menin. Although mutations of the MEN1 gene are …

Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response

V Busygina, MC Kottemann, KL Scott, SE Plon, AE Bale - Cancer research, 2006 - AACR
Multiple endocrine neoplasia type 1 (MEN1) is a cancer susceptibility syndrome affecting
several endocrine tissues. Investigations of the biochemical function of the MEN1 protein …

Mechanisms of disease: multiple endocrine neoplasia type 1—relation to chromatin modifications and transcription regulation

KMA Dreijerink, JWM Höppener… - Nature Clinical Practice …, 2006 - nature.com
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome characterized
by tumors of the parathyroid glands, the pancreatic islets, the pituitary gland, the adrenal …

[PDF][PDF] Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis

PJ Zindy, A L'Helgoualc'h, D Bonnier, A Le Béchec… - …, 2006 - Wiley Online Library
The molecular mechanisms underlying the progression of cirrhosis toward hepatocellular
carcinoma were investigated by a combination of DNA microarray analysis and literature …

[HTML][HTML] Cancer issue: Multiple Endocrine Neoplasia Type 1 (MEN1) as a Cancer Predisposition Syndrome: Clues into the Mechanisms of MEN1-related …

V Busygina, AE Bale - The Yale journal of biology and medicine, 2006 - ncbi.nlm.nih.gov
Cancer is a major public health problem in the United States and around the world with
millions of new cases diagnosed each year. While most of the cancers occur sporadically, a …