The involvement of the vascular system in malignancy encompasses not only angiogenesis,
but also systemic hypercoagulability and a pro‐thrombotic state, and there is increasing …

The glycosaminoglycan heparin is a polyanionic polysaccharide most recognized for its
anticoagulant activity. Heparin binds to cationic regions in hundreds of prokaryotic and …

Heparanase is an endoglycosidase that cleaves heparan sulfate (HS), the main
polysaccharide of the basement membrane (BM). HS is responsible for BM integrity and …

The minimal signalling unit for tyrosine kinase receptors is two protomers dimerized by one
or more ligands. However, it is clear that maximal signalling requires the formation of larger …

Angiogenesis plays a key role in various physiological and pathological processes,
including inflammation and tumor growth. Numerous angiogenic growth factors (AGFs) have …

The diversity-oriented chemical modification of heparin is shown to afford charge-reduced
heparin derivatives that possess increased selectivity for binding heparin-binding proteins …