Parkinson's disease (PD) is a neurodegenerative disease that is both common and
incurable. The majority of cases are sporadic and of unknown origin but several genes have …

1. Introduction 22. Sources of structural information in solid-state NMR data 52.1 General
remarks 52.2 Chemical shifts, linewidths, and magic-angle spinning 62.3 Dipole–dipole …

A comprehensive, unbiased inventory of synuclein forms present in Lewy bodies from
patients with dementia with Lewy bodies was carried out using two-dimensional immunoblot …

The synucleins are a family of intrinsically disordered proteins involved in various human
diseases. α‐Synuclein has been extensively characterized due to its role in Parkinson's …

α-Synuclein is the major component of the filamentous inclusions that constitute defining
characteristics of Parkinson's disease and other α-synucleinopathies. Here we have tested …

Sumoylation is an important post-translational modification that provides a rapid and
reversible means for controlling the activity, subcellular localization, and stability of target …

The aggregation of α‐synuclein (αS) in the brain has been implicated as a critical step in the
development of Lewy body diseases (LBD) and multiple system atrophy (MSA). Various …

Dysfunction of the 140 aa protein α-synuclein plays a central role in Lewy body disorders,
including Parkinson's disease, as well as in multiple system atrophy. Here, we show that the …

Formation of α-synuclein aggregates is proposed to be a crucial event in the pathogenesis
of Parkinson's disease. Large soluble oligomeric species are observed as probable …

Abstract α-Synuclein aggregation is thought to be a key event in the pathogenesis of
synucleinopathies. Although different α-synuclein alterations and modifications have been …