Some psychoactive drugs are abused because of their ability to act as reinforcers. As a
consequence behavioural patterns (such as drug‐seeking/drug‐taking behaviours) are …

Background and rationale The reinstatement model is widely used to study relapse to drug
addiction. However, the model's validity is open to question. Objective We assess the …

Using a rat relapse model, we previously reported that re-exposing rats to a drug-associated
context, following extinction of operant responding in a different context, reinstates heroin …

This article represents the proceedings of a symposium presented at the 158th Annual
Meeting of the American Psychiatric Association held in Atlanta, Georgia, on May 24, 2005 …

The aim of the present experiment was to investigate the effects of cocaine primes and
exposure to foot shock stress on reinstatement of operant responding maintained by a …

Observing responses produce contact with stimuli that are to be discriminated and have
been considered an animal model of attending. In the observing-response procedure …

This thesis describes an investigation of the pattern of cellular activity displayed within the
medial prefrontal cortex (mPFC), amygdala and the nucleus accumbens (Acb) during the …

This thesis describes an investigation of the pattern of cellular activity displayed within the
medial prefrontal cortex (mPFC), amygdala and the nucleus accumbens (Acb) during the …

Caffeine is the most widely consumed psychoactive drug, with the prevalence of use
approaching 80% of the world's population. In stark contrast to most stimulants, caffeine is …

The prefrontal cortex (PFC) is a heterogeneous brain structure and the contributions of this
memory system to drug addiction are poorly understood. This dissertation investigated two …