The resurgence of research in podocyte biology over the past decade underscores the
importance of this unique cell in preserving glomerular structure and function. A greater …

A properly established and maintained podocyte intercellular junction, or slit diaphragm, is a
necessary component of the selective permeability barrier of the kidney glomerulus. The …

Recent clinical studies implicate proteinuria as a key prognostic factor for renal and
cardiovascular complications in hypertensives. The pathogenesis of proteinuria in …

Toll-like receptors (TLRs) are proteins that recognize specific molecular patterns of
pathogens. They can also interact with a variety of endogenous ligands. When stimulated …

Murine CMV (MCMV), a β-herpesvirus, infects dendritic cells (DC) and impairs their function.
The underlying events are poorly described. In this study, we identify MCMV m138 as the …

Podocyte apoptosis initiates progressive glomerulosclerosis in TGF-β1 transgenic and
CD2AP-knockout (CD2AP−/−) mice. It was previously shown that in both mouse models …

Background/Aims: We report on the isolation of a factor secreted by peripheral blood
mononuclear cells from patients with idiopathic minimal lesion nephrotic syndrome (IMLNS) …

DISCUSSION Proteinuria following renal transplantation may result from diverse
pathogenetic mechanisms, with different implications for graft survival. Proteinuria in the first …

CASE PRESENTATION A 42-year-old Caucasian woman with AIDS presented with new
onset severe lower extremity edema and progressive renal failure. She had a 14-year …

Podocyty odgrywają główną rolę w prawidłowym funkcjonowaniu kłębuszka nerkowego.
Oprócz komórek śródbłonka pętli włośniczkowej i kłębuszkowej błony podstawnej wchodzą …