Activating tyrosine kinase (TK) mutations disrupt cellular proliferation and survival pathways
and are increasingly recognized as a fundamental cause of human cancers. Until very …

Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia
associated with a poor prognosis. However, there are relatively few insights into the genetic …

Myelofibrosis with myeloid metaplasia (MMM) is currently classified as a classic (ie not yet
molecularly defined) myeloproliferative disorder (MPD), along with essential …

BACKGROUND Allogeneic hematopoietic stem cell transplantation is potentially curative in
agnogenic myeloid metaplasia (AMM) but is associated with substantial mortality and …

We report a case of a patient with myelofibrosis with myeloid metaplasia (MMM) who
presented with progressive dyspnea of unexplained origin. Splenomegaly, blood smear …

Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with
myeloid metaplasia (MMM) 72% carried the JAK2V617F mutation. The mutation was …

Context.—Chronic idiopathic myelofibrosis (CIMF) is a clonal myeloproliferative disease
characterized by panmyelosis with intact maturation, progressive bone marrow fibrosis, and …

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the clinical manifestations of myelofibrosis with myeloid metaplasia and recent …

Myeloid sarcoma (MS) is a neoplastic growth of myeloblasts or immature myeloid cells
arising in an extra-medullary site or in the bone. MS may precede, occur simultaneously or …

Chronic idiopathic myelofibrosis (CIMF) is a chronic myeloproliferative disorder (CMPD) with
progressive fibrosis and extramedullary hematopoiesis. Similar to other CMPDs, the stem …