Autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney
disease are the best known of a large family of inherited diseases characterized by the …

The interaction of ion channels with the actin-based cytoskeleton in epithelial cells not only
maintains the polarized expression of ion channels within specific membrane domains, it …

Penile erection is a complicated event involving the regulation of corpus cavernosal smooth
muscle tone. Recently, the small monomeric G-protein RhoA and its downstream effector …

Trafficking of water channel aquaporin-2 (AQP2) to the apical membrane is critical to water
reabsorption in renal collecting ducts and its regulation maintains body water homeostasis …

Activity of the epithelial Na+ channel (ENaC) is limiting for Na+ absorption across many
epithelia. Consequently, ENaC is a central effector impacting systemic blood volume and …

The serine/threonine phosphatase calcineurin is an important signaling molecule involved
in kidney development and function. One potential target of calcineurin action is the water …

IIZPXYDJLKNOIY-JXPKJXOSSA-O 2-[[(2R)-3-hexadecanoyloxy-2-[(5Z, 8Z, 11Z, 14Z)-icosa-
5, 8, 11, 14-tetraenoyl] oxypropoxy]-hydroxyphosphoryl] oxyethyl-trimethylazanium …

Aquaporin-2 (AQP2), when expressed in fully differentiated 3T3-L1 adipocytes, displays
cAMP-dependent plasma membrane translocation in a manner similar to its behavior in …

In neuronal cells, current evidence suggests that G13α and RhoA play significant roles in
LPA-mediated neurite retraction; however, the contribution of other G-proteins to this …

Oxidized phospholipids (OxPL) appear in the lung circulation as a result of increased
oxidative stress that accompanies pathological conditions such as acute lung injury, lung …