Neuroanatomical and pharmacological evidence implicates glutamate transmission in drug-
environment conditioning that partly controls drug seeking and relapse. Glutamate receptors …

Blockade of cannabinoid CB1 receptors has been reported to inhibit cocaine-or cocaine cue-
induced reinstatement of drug seeking. However, the mechanisms underlying this action are …

Background Among the multiple mechanisms of action of topiramate, AMPA/kainate
antagonism may be particularly interesting for the treatment of disorders characterized by …

Drugs of abuse affect behavior by altering neuronal communication within the brain.
Previous research examining the effects of intraperitoneally administered cocaine has …

Due to its AMPA (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid)/kainate
antagonism, topiramate would be particularly interesting in addiction treatment. Flexible …

Abstract Rationale Fischer 344 (F344) and Lewis (LEW) rats differ in cocaine self-
administration behaviors. Whether or not these inbred strains of rats differ in …

The present series of experiments examined the involvement of the σ 1 receptor and related
neuroactive steroids in the memory state induced by a very low dose of cocaine. Using a …

An environment previously associated with cocaine use can elicit cravings, even in the
absence of the drug, which may be due to the formation of strong associations between the …

The characteristics of drug addiction include compulsive drug use despite negative
consequences and re-occurring relapses, returns to drug use after a period of abstinence …

The work presented in this thesis aimed to investigate the consequences and causes of
ketamine abuse and compare them with the acute effects of the drug. Seven experimental …