Major depressive disorder (MDD) is common and moderately heritable. Recurrence and
early age at onset characterize cases with the greatest familial risk. Major depressive …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The concept that genetic factors contribute to the complex trait of suicidal behaviour has
stimulated much work aimed at identifying susceptibility genes. So far molecular genetic …

Objective: Although it is well established that depressive symptoms are associated with
recurrent cardiac events among cardiac patients and novel cardiac events among …

The study of the genetics of complex behaviors has evolved dramatically from the days of
the nature versus nurture debates that dominated much of the past century. Here we discuss …

The major findings regarding the genetics of stress response and stress-related disorders
are:(i) variations in genes involved in the sympathetic system or in the hypothalamic-pituitary …

Context Tryptophan hydroxylase is the rate-limiting enzyme in the serotonin (5-HT)
biosynthetic pathway responsible for the regulation of serotonin levels. Tryptophan …

Suicide is a major public health issue, especially in western countries, accounting for
approximately 1 million deaths every year throughout the world. The tryptophan hydroxylase …

Many neuropsychiatric disorders are considered to be related to the dysregulation of brain
serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific …

Objective: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme
in the biosynthesis of serotonin, has many biological functions and plays an important role …