Protein–protein interactions as targets for small molecule drug discovery
DC Fry - Peptide Science: Original Research on Biomolecules, 2006 - Wiley Online Library
Protein–protein interactions represent a highly populated class of targets for drug discovery.
However, such systems present a number of unique challenges. This review presents an …
However, such systems present a number of unique challenges. This review presents an …
[HTML][HTML] Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of …
T Samuel, K Welsh, T Lober, SH Togo… - Journal of Biological …, 2006 - ASBMB
Inhibitor of apoptosis proteins (IAPs) regulate apoptosis primarily by inhibiting caspase-
family proteases. However, many IAPs also possess E3 ligase (ubiquitin-protein isopeptide …
family proteases. However, many IAPs also possess E3 ligase (ubiquitin-protein isopeptide …
Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic
H Sun, Z Nikolovska-Coleska, J Lu, S Qiu… - Journal of medicinal …, 2006 - ACS Publications
A potent, cell-permeable, conformationally constrained second mitochondria derived
activator of caspase mimetic (SM-131, 2) has been designed, synthesized, and evaluated …
activator of caspase mimetic (SM-131, 2) has been designed, synthesized, and evaluated …
Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein
J Chen, Z Nikolovska-Coleska, G Wang, S Qiu… - Bioorganic & medicinal …, 2006 - Elsevier
X-Linked inhibitor of apoptosis protein (XIAP) is a promising molecular target for the design
of new anticancer drugs aiming at promoting apoptosis in cancer cells. We have previously …
of new anticancer drugs aiming at promoting apoptosis in cancer cells. We have previously …
[HTML][HTML] Development of peptidomimetics targeting IAPs
SK Sharma, C Straub, L Zawel - International journal of peptide research …, 2006 - Springer
Inhibitor of apoptosis proteins (IAPs) such as XIAP subvert apoptosis by binding and
inhibiting caspases. Because occupation of the XIAP BIR3 peptide binding pocket by Smac …
inhibiting caspases. Because occupation of the XIAP BIR3 peptide binding pocket by Smac …
Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain
K Taylor, D Micha, M Ranson, C Dive - Expert opinion on …, 2006 - Taylor & Francis
Apoptosis is a fundamental cellular death process that is essential for normal tissue
homeostasis, whose deregulation is associated with several human disease states …
homeostasis, whose deregulation is associated with several human disease states …
Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library
MC Sweeney, X Wang, J Park, Y Liu, D Pei - Biochemistry, 2006 - ACS Publications
Inhibitor of apoptosis (IAP) proteins regulate programmed cell death by inhibiting members
of the caspase family of proteases. The X-chromosome-linked IAP (XIAP) contains three …
of the caspase family of proteases. The X-chromosome-linked IAP (XIAP) contains three …
[HTML][HTML] Role of the Met3534–Ala4271 region of the ryanodine receptor in the regulation of Ca2+ release induced by calmodulin binding domain peptide
JP Gangopadhyay, N Ikemoto - Biophysical journal, 2006 - cell.com
CaMBP, a peptide corresponding to the 3614–3643 calmodulin (CaM) binding region of the
ryanodine receptor (RyR1), is known to activate RyR1 Ca 2+ channel. To analyze the …
ryanodine receptor (RyR1), is known to activate RyR1 Ca 2+ channel. To analyze the …
Tryptophan and tyrosine to terbium fluorescence resonance energy transfer as a method to “map” aromatic residues and monitor docking
JE Allen, GL McLendon - Biochemical and biophysical research …, 2006 - Elsevier
Fluorescent lanthanide ions, with large Stokes shifts and narrow emission bands, are
excellent tools for the development of FRET-based assays. In this work, a terbium ion is …
excellent tools for the development of FRET-based assays. In this work, a terbium ion is …
Cytochrome P450 enzymes: Computational approaches to substrate prediction
A Verras, ID Kuntz, PRO de Montellano - Annual Reports in Computational …, 2006 - Elsevier
Publisher Summary This chapter discusses the P450 structural information gleaned over the
last 20 years from crystallography and homology modeling, structure-based approaches …
last 20 years from crystallography and homology modeling, structure-based approaches …