The chemokine SDF-1 (CXCL12) and its receptor CXCR4 are involved in regulation of
migration, survival, and development of multiple cell types, including human hematopoietic …

Hematopoietic stem cell transplantation (HSCT) has become the standard of care for the
treatment of many hematologic malignancies, chemotherapy sensitive relapsed acute …

The long-term survival of patients with acute myeloid leukemia (AML) is dismally poor. A
permanent cure of AML requires elimination of leukemic stem cells (LSCs), the only cell type …

The epithelial components of the mammary gland are thought to arise from stem cells with a
capacity for self-renewal and multilineage differentiation. Furthermore, these cells and/or …

In a previous investigation, we demonstrated that mesenchymal stem cells (MSCs) actively
migrated to cardiac allografts and contributed to graft fibrosis and, to a lesser extent, to …

In individuals with chronic myeloid leukemia (CML) treated by autologous hematopoietic
stem cell (HSC) transplantation, malignant progenitors in the graft contribute to leukemic …

The mechanisms leading to prostate cancer metastasis are not understood completely.
Although there is evidence that the CXC chemokine receptor (CXCR) 4 and its ligand …

Several components of the essential process of stem cell homing have now been
characterized. Cell adhesion molecules and their ligands, extracellular matrix components …

The laminin receptor integrin α6 chain is ubiquitously expressed in human and mouse
hematopoietic stem and progenitor cells. We have studied its role for homing of stem and …

Hyaluronan (HA), in the bone marrow stroma, is the major non‐protein glycosaminoglycan
component of extracellular matrix (ECM) involved in cell positioning, proliferation …