Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The peripheral anionic site of acetylcholinesterase lies at the entrance to the active site
gorge. It is composed of five residues (Tyr 70, Asp 72, Tyr 121, Trp 279 and Tyr 334; …

Although the hallmarks of neurodegeneration in Alzheimer's brains are well known, one of
the current difficulties is related to the lack of solid evidence about the ultimate factors that …

Kinetic parameters of the effect of tacrine as a cholinesterase inhibitor have been studied in
two different sources: snake venom (Bungarus sindanus) acetylcholinesterase (AChE) and …

Novel highly affine histamine H3 receptor ligands with additional inhibitory effects on the
main histamine metabolizing enzyme in the brain, N-methyltransferase, chemically show …

Introduction. Among the numerous pathophysiological theories that attempt to explain the
development of Alzheimer's disease (AD) there are two facts that stand out above the rest …

An explosion in the incidence of neurodegenerative diseases, particularly Alzheimer's
disease (AD), is predicted in coming decades. Hence, the need to devise and assess new …

Accompanying the gradual rise in the average age of the population of most industrialized
countries is a regrettable progressive rise in the number of individuals afflicted with age …