In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …

Insulin has pleiotropic biological effects in virtually all tissues. However, the relevance of
insulin signaling in peripheral tissues has been studied far more extensively than its role in …

Leptin and insulin have been identified as fuel sensors acting in part through their
hypothalamic receptors to inhibit food intake and stimulate energy expenditure. As their …

Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of
cAMP‐regulated guanine nucleotide exchange factors (cAMPGEFs) that mediate protein …

Summary Hyperpolarization-activated, cyclic-nucleotide-gated (HCN) channels mediate the
depolarizing cation current (termed I h or I f) that initiates spontaneous rhythmic activity in …

The Epac family of cAMP‐regulated guanine nucleotide exchange factors (cAMPGEFs, also
known as Epac1 and Epac2) mediate stimulatory actions of the second messenger cAMP on …

We have reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 (CYP)
epoxygenase metabolites of arachidonic acid (AA), are potent sarcolemmal ATP‐sensitive …

Phosphoinositides (PIPns) are known to regulate the activity of some ion channels. Here we
determined that ATP‐gated P2X2 channels also are regulated by PIPns, and investigated …

The β-cell ATP-sensitive potassium (K ATP) channel controls insulin secretion by linking
glucose metabolism to membrane excitability. Loss of K ATP channel function due to …

ATP-sensitive K+ channels (KATP channels) couple cell metabolism to electrical activity and
thereby to physiological processes such as hormone secretion, muscle contraction, and …